CB2 receptor agonist 8

CB2 receptor agonist 8 (Compound 17) is an agonist for cannabinoid receptor 2 (CB2 receptor) . CB2 receptor agonist 8 exhibits cytotoxicity in cells U87, RPMI 8226, HL-60, and L929 with IC50s of 91.03, 16.29, 23.51 and 564.6 μM, respectively. CB2 receptor agonist 8 activates caspase 3/7, increases the expressions of pro-apoptotic genes BAX, BAD, BIM and tumor suppressor genes p53, and induces apoptosis in U87. CB2 receptor agonist 8 inhibits the migration of U87[1].

Product Specifications

UNSPSC

12352005

Target

Cannabinoid Receptor; Caspase

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cb2-receptor-agonist-8.html

Smiles

O=C(N[C@H](C(N)=O)C(C)(C)C)CC1=CN(CC2=CC=CC=C2)C3=CC=C(F)C=C31

Molecular Formula

C23H26FN3O2

Molecular Weight

395.47

References & Citations

[1]Doganc F, et al., Synthesis of novel indol-3-acetamido analogues as potent anticancer agents, biological evaluation and molecular modeling studies. Bioorg Chem. 2024 Jul;148:107429.