CB2 receptor agonist 8
CB2 receptor agonist 8 (Compound 17) is an agonist for cannabinoid receptor 2 (CB2 receptor) . CB2 receptor agonist 8 exhibits cytotoxicity in cells U87, RPMI 8226, HL-60, and L929 with IC50s of 91.03, 16.29, 23.51 and 564.6 μM, respectively. CB2 receptor agonist 8 activates caspase 3/7, increases the expressions of pro-apoptotic genes BAX, BAD, BIM and tumor suppressor genes p53, and induces apoptosis in U87. CB2 receptor agonist 8 inhibits the migration of U87[1].
Product Specifications
UNSPSC
12352005
Target
Cannabinoid Receptor; Caspase
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cb2-receptor-agonist-8.html
Smiles
O=C(N[C@H](C(N)=O)C(C)(C)C)CC1=CN(CC2=CC=CC=C2)C3=CC=C(F)C=C31
Molecular Formula
C23H26FN3O2
Molecular Weight
395.47
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB2
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