TCS1105

TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion[1][2].

Product Specifications

CAS Number

[185391-33-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tcs1105.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=C(F)C=C1)C(C2=CNC3=C2C=CC=C3)=O

Molecular Formula

C17H13FN2O2

Molecular Weight

296.30

Precautions

H302, H315, H319

References & Citations

[1]van der Kooij MA, et al. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats. Neuropharmacology. 2018 Aug;138:275-281.|[2]Xu J, et al. Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol Teratol. 2019 Jul-Aug;74:106812.