Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Niraparib (R-enantiomer)

Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM.

Product Specifications

CAS Number

1038915-58-0

Product Name Alternative

MK 4827 (R-enantiomer)

UNSPSC

12352005

Hazard Statement

H315, H319

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MK-4827_R-enantiomer.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC2=CN(C3=CC=C([C@@H]4CNCCC4)C=C3)N=C12)N

Molecular Formula

C19H20N4O

Molecular Weight

320.39

Precautions

H315, H319

References & Citations

[1]Jones P, et al. Discovery of 2-{4-[ (3S) -piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827) : a novel oral poly (ADP-ribose) polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52 (22) :7170-85.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP1

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

C20orf31 (EDEM2) (NM_001145025) Human Over-expression Lysate
LY428649 100 µg

C20orf31 (EDEM2) (NM_001145025) Human Over-expression Lysate

Sign In for Pricing
View Details
FAM90A8P (NM_001164450) Human Over-expression Lysate
LC431409 20 µg

FAM90A8P (NM_001164450) Human Over-expression Lysate

Sign In for Pricing
View Details
Cytochrome P450 17A1 (CYP17A1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI9H4]
TA503395AM 100 µL

Cytochrome P450 17A1 (CYP17A1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI9H4]

Sign In for Pricing
View Details
Veratric Acid 4-Chlorobutyl Ester
TRC-V127565-5G 5 g

Veratric Acid 4-Chlorobutyl Ester

Sign In for Pricing
View Details
SENP6 Rabbit Polyclonal Antibody
AP06460PU-N 100 µg

SENP6 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
CytoTell® Violet 500
22248-AAT 500 Tests

CytoTell® Violet 500

Sign In for Pricing
View Details