Niraparib (R-enantiomer)

Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM.

Product Specifications

CAS Number

[1038915-58-0]

Product Name Alternative

MK 4827 (R-enantiomer)

UNSPSC

12352005

Hazard Statement

H315, H319

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MK-4827_R-enantiomer.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC2=CN(C3=CC=C([C@@H]4CNCCC4)C=C3)N=C12)N

Molecular Formula

C19H20N4O

Molecular Weight

320.39

Precautions

H315, H319

References & Citations

[1]Jones P, et al. Discovery of 2-{4-[ (3S) -piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827) : a novel oral poly (ADP-ribose) polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52 (22) :7170-85.