(rac) -Methyl jasmonate

(rac) -Methyl jasmonate is the racemate of Methyl jasmonate (HY-135663) . Methyl jasmonate is a phytohormone that regulates the defense response of plants under biotic and biotic stress through jasmonate signaling pathway. Methyl jasmonate inhibits the activation of NF-κB signaling pathway. Methyl jasmonate can promote the mitochondrial ROS production, but also scavenges free radicals and reduces the oxidative stress. Methyl jasmonate exhibits anti-inflammatory, antitumor, anticonvulsant, antinociceptive and sedative activities[1][2][3][4][5][6].

Product Specifications

CAS Number

[39924-52-2]

UNSPSC

12352211

Hazard Statement

H302, H319

Target

Apoptosis; Glutathione Peroxidase; NF-κB; Phytohormone; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/methyl-2-3-oxo-2-pent-2-en-1-yl-cyclopentyl-acetate.html

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC)CC1C(C/C=C/CC)C(CC1)=O

Molecular Formula

C13H20O3

Molecular Weight

224.30

Precautions

H302, H319

References & Citations

[1]Pereira-Maróstica HV, et al., Methyl Jasmonate Reduces Inflammation and Oxidative Stress in the Brain of Arthritic Rats. Antioxidants (Basel) . 2019 Oct 15;8 (10) :485.|[2]Yu X, et al., The roles of methyl jasmonate to stress in plants. Funct Plant Biol. 2019 Feb;46 (3) :197-212.|[3]Tong QS, et al., Methyl jasmonate downregulates expression of proliferating cell nuclear antigen and induces apoptosis in human neuroblastoma cell lines. Anticancer Drugs. 2008 Jul;19 (6) :573-81.|[4]Annafi OS, et al., Evaluation of the anticonvulsant and anxiolytic potentials of methyl jasmonate in mice. Sci Pharm. 2014 Mar 24;82 (3) :643-54.|[5]Eduviere AT, et al., Methyl jasmonate enhances memory performance through inhibition of oxidative stress and acetylcholinesterase activity in mice. Life Sci. 2015 Jul 1;132:20-6.|[6]Umukoro S, et al., Antinociceptive effects of methyl jasmonate in experimental animals. J Nat Med. 2011 Jul;65 (3-4) :466-70.