ML406

ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis[1].

Product Specifications

CAS Number

[774589-47-8]

UNSPSC

12352005

Hazard Statement

H410

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ml406.html

Purity

99.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(N2CCN(C(C3=CC=C(OCO4)C4=C3)=O)CC2)C=C1)=O

Molecular Formula

C20H20N2O4

Molecular Weight

352.38

Precautions

H410

References & Citations

[1]Casalena D, et al. Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition. 2014 Apr 15 [updated 2015 Jan 16]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD) : National Center for Biotechnology Information (US) ; 2010–.