Necrostatin-7
Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase[1].
Product Specifications
CAS Number
351062-08-3
Product Name Alternative
Nec-7
UNSPSC
12352005
Hazard Statement
H302
Target
Necroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/necrostatin-7.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1N(C2=NC=CS2)C(S/C1=C\C3=CNN=C3C4=CC=C(F)C=C4)=N
Molecular Formula
C16H10FN5OS2
Molecular Weight
371.41
Precautions
P264-P270-P330-P501
References & Citations
[1]Weihong Zheng, et al. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett. 2008 Sep 15;18 (18) :4932-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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