CP671305

CP671305 is a potent, orally active, selective inhibitor of phosphodiesterase-4-D, and possesses high activities.

Product Specifications

CAS Number

[445295-04-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/CP671305.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](OC1=CC=C(CNC(C2=CC=CN=C2OC3=CC=C(OCO4)C4=C3)=O)C(F)=C1)C(O)=O

Molecular Formula

C23H19FN2O7

Molecular Weight

454.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Kalgutkar AS, et al. Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+) -2-[4- ({[2- (benzo[1,3]dioxol-5-yloxy) -pyridine-3-carbonyl]-amino}-methyl) -3-fluoro-phenoxy]-propionic acid in rat and human. Drug Metab Dispos. 2007 Nov;35 (11) :2111-8. Epub 2007 Aug 8.|[2]Kalgutkar AS, et al. Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species. Xenobiotica. 2004 Aug;34 (8) :755-70.