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Ramosetron (Hydrochloride)

Ramosetron (YM060 free base) Hydrochloride is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron Hydrochloride is promising for research of irritable bowel syndrome with diarrhea[1][2][3][4].

Product Specifications

CAS Number

132907-72-3

Product Name Alternative

YM060

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ramosetron-Hydrochloride.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 32 mg/mL (ultrasonic; warming) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H](C3)CCC4=C3NC=N4.Cl

Molecular Formula

C17H18ClN3O

Molecular Weight

315.80

Precautions

H302

References & Citations

[1]http://www.drugsupdate.com/generic/view/1111|[2]Yasuda M, et al. 5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. Br J Pharmacol. 2013 Mar;168 (6) :1388-400.|[3]Kojima SI, et al. Investigation of 5-HT3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell. Eur J Pharmacol. 2017 Mar 15;799:196-200. |[4]Fukudo S, et al. Ramosetron Reduces Symptoms of Irritable Bowel Syndrome With Diarrhea and Improves Quality of Life in Women. Gastroenterology. 2016 Feb;150 (2) :358-66.e8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Lactoferrin

Available Sizes

Frequently Asked Questions

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