Ganoderenic acid K

Ganoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum. Ganoderenic acid K shows strong inhibitory activity against HMG-CoA reductase (HMGCR) with IC50 of 16.5 μM[1].

Product Specifications

CAS Number

[942950-94-9]

UNSPSC

12352211

Target

HMG-CoA Reductase (HMGCR)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ganoderenic-acid-k.html

Purity

99.64

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]([C@@H](C(C3=C1[C@H](C[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)O)C)O)=O)OC(C)=O)([C@H](CC2=O)/C(C)=C/C(CC(C)C(O)=O)=O)C

Molecular Formula

C32H44O9

Molecular Weight

572.69

References & Citations

[1]Chen B, et al. Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMGs reductase, aldose reductase and α-glucosidase. Fitoterapia. 2017 Jul;120:6-16.