ITCH / AIP4 Recombinant Rabbit Monoclonal Antibody [JE31-09]
ITCH is a HECT domain–containing E3 ubiquitin ligase that is ablated in non-agouti-lethal 18H (aka Itchy) mice. Itchy mice develop a severe immunological phenotype after birth that includes hyperplasia of lymphoid and hematopoietic cells, and stomach and lung inflammation. In humans ITCH deficiency causes altered physical growth, craniofacial morphology defects, defective muscle development, and aberrant immune system function. The ITCH gene is located on chromosome 20 in humans. ITCH contains a C2 domain, proline-rich region, WW domains, HECT domain, and multiple amino acids that are phosphorylated and ubiquitinated.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ITCH
Swiss Prot
Q96J02 Human, Q8C863 Mouse,
Cellular Locus
Cell membrane, Cytoplasm, Nucleus, Early endosome membrane, Endosome membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within
Isotype
IgG
Clone
JE31-09
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
SiHa cell lysate, HeLa cell lysate, Ramos cell lysate, NIH/3T3 cell lysate, C6 cell lysate, PC-12 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 103 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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