IMT1
Product Specifications
UNSPSC Description
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1].
Target Antigen
DNA/RNA Synthesis; Mitochondrial Metabolism; Oxidative Phosphorylation
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/imt1.html
Smiles
CC(OC1=CC=C(C(O2)=C1)C(C3=CC=CC=C3C)=CC2=O)C(N(C)C)=O
Molecular Weight
351.40
References & Citations
[1]Nina A Bonekamp, et al. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134539/IMT1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134539/IMT1-SDS-MedChemExpress.pdf
CAS Number
2304621-31-4
Available Sizes
Curated Selection
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