Ketanserin
Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM) .
Product Specifications
CAS Number
74050-98-9
Product Name Alternative
R41468
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; Autophagy; Potassium Channel
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ketanserin.html
Concentration
10mM
Purity
99.89
Solubility
DMF : 5 mg/mL (ultrasonic) |DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1N2)N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C2=O
Molecular Formula
C22H22FN3O3
Molecular Weight
395.43
Precautions
H302
References & Citations
[1]Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155 (3) :365-73.|[2]Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.|[3]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340 (2) :369-76.|[4]Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11 (9) :1471-1479.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α-1 microglobulin
Available Sizes
Frequently Asked Questions
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