Ketanserin

Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM) .

Product Specifications

CAS Number

[74050-98-9]

Product Name Alternative

R41468

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor; Autophagy; Potassium Channel

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ketanserin.html

Concentration

10mM

Purity

99.89

Solubility

DMF : 5 mg/mL (ultrasonic) |DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1N2)N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C2=O

Molecular Formula

C22H22FN3O3

Molecular Weight

395.43

Precautions

H302

References & Citations

[1]Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155 (3) :365-73.|[2]Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.|[3]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340 (2) :369-76.|[4]Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11 (9) :1471-1479.