Clopidogrel (hydrogen sulfate)

Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]．Clopidogrel hydrogen sulfate also is an orally active P2Y (12) inhibitor[5].

Product Specifications

CAS Number

[120202-66-6]

Product Name Alternative

(S) - (+) -Clopidogrel bisulfate; (S) - (+) -Clopidogrel hydrogen sulfate

UNSPSC

12352005

Hazard Statement

H314, H318, H401, H411

Target

Cytochrome P450; P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Clopidogrel-hydrogen-sulfate.html

Purity

99.88

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

ClC1=C([C@@H](C(OC)=O)N2CCC3=C(C=CS3)C2)C=CC=C1.O=S(O)(O)=O

Molecular Formula

C16H18ClNO6S2

Molecular Weight

419.90

Precautions

H314, H318, H401, H411

References & Citations

[1]Katsunobu Hagihara, et al. Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, Clopidogrel, and ticlopidine. Drug Metab Pharmacokinet. 2008;23 (6) :412-20.|[2]Jean-Marc Herbert, et al. P2Y12, a new platelet ADP receptor, target of Clopidogrel.Semin Vasc Med. 2003 May;3 (2) :113-22.|[3]Hai-Lu Wu, et al. Increased endoplasmic reticulum stress response is involved in Clopidogrel-induced apoptosis of gastric epithelial cells. PLoS One. 2013 Sep 13;8 (9) :e74381.|[4]Ran Ni, et al. Effect of Different Doses of Acetylsalicylic Acid on the Antithrombotic Activity of Clopidogrel in a Mouse Arterial Thrombosis Model.Arterioscler Thromb Vasc Biol. 2018 Oct;38 (10) :2338-2344.|[5]Kuszynski DS, et al. Clopidogrel treatment inhibits P2Y2-Mediated constriction in the rabbit middle cerebral artery [published online ahead of print, 2021 Oct 1]. Eur J Pharmacol. 2021;174545.