Naphthofluorescein

Naphthofluorescein inhibits the interaction between HIF-1 and Mint3. Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo[1]. Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging[2].

Product Specifications

CAS Number

[61419-02-1]

Product Name Alternative

Naphthafluorescein

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/naphthofluorescein.html

Purity

99.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC=C1)OC32C4=C(OC5=C3C=CC6=CC(O)=CC=C56)C7=CC=C(O)C=C7C=C4

Molecular Formula

C28H16O5

Molecular Weight

432.42

Precautions

H315, H319, H335

References & Citations

[1]Sakamoto T, et al. Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock. Commun Biol. 2021;4 (1) :1165. Published 2021 Oct 7. |[2]Arroyo AD, et al. Development of fluorinated naphthofluoresceins for Cerenkov imaging. J Fluor Chem. 2019;225:27-34.