Spiclomazine
Spiclomazine (Clospirazine) is a potent mutant KRAS (G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].
Product Specifications
CAS Number
[24527-27-3]
Product Name Alternative
Clospirazine
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spiclomazine.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1
Molecular Formula
C22H24ClN3OS2
Molecular Weight
446.03
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
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