μ-Conotoxin SIIIA

<strong>μ-Conotoxin SIIIA</strong> <strong>Catalog number:</strong> MDP0800 <strong>CAS Number: </strong>131438-74-9 <strong>Sequence: </strong>Pyr-Asn-Cys-Cys-Asn-Gly-Gly-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH2 (Disulfide bonds between Cys3-Cys13, Cys4-Cys19, and Cys8-Cys20) <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 2207.2 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Akondi KB, Lewis RJ, Alewood PF. Re-engineering the μ-conotoxin SIIIA scaffold Biopolymers. 2014 Apr;101(4):347-54. 2: Wang CZ, Zhang H, Jiang H, Lu W, Zhao ZQ, Chi CW. A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels Toxicon. 2006 Jan;47(1):122-32. 3: Dhiman V, Pant D. Human health and snails J Immunoassay Immunochem. 2021 May 4;42(3):211-235. 4: Yao S, Zhang MM, Yoshikami D, Azam L, Olivera BM, Bulaj G, Norton RS. Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA Biochemistry. 2008 Oct 14;47(41):10940-9. 5: Schroeder CI, Ekberg J, Nielsen KJ, Adams D, Loughnan ML, Thomas L, Adams DJ, Alewood PF, Lewis RJ. Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels J Biol Chem. 2008 Aug 1;283(31):21621-8. 6: Leipold E, Markgraf R, Miloslavina A, Kijas M, Schirmeyer J, Imhof D, Heinemann SH. Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels Neuropharmacology. 2011 Jul-Aug;61(1-2):105-11. 7: Heimer P, Tietze AA, Böhm M, Giernoth R, Kuchenbuch A, Stark A, Leipold E, Heinemann SH, Kandt C, Imhof D. Application of room-temperature aprotic and protic ionic liquids for oxidative folding of cysteine-rich peptides Chembiochem. 2014 Dec 15;15(18):2754-65. 8: Leipold E, Ullrich F, Thiele M, Tietze AA, Terlau H, Imhof D, Heinemann SH. Subtype-specific block of voltage-gated K(+) channels by μ-conopeptides Biochem Biophys Res Commun. 2017 Jan 22;482(4):1135-1140. 9: Green BR, Catlin P, Zhang MM, Fiedler B, Bayudan W, Morrison A, Norton RS, Smith BJ, Yoshikami D, Olivera BM, Bulaj G. Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity Chem Biol. 2007 Apr;14(4):399-407. <a href="https://pubmed.ncbi.nlm.nih.gov/30893914">10: Kaufmann D, Tietze AA, Tietze D. In Silico Analysis of the Subtype Selective Blockage of KCNA Ion Channels through the µ-Conotoxins PIIIA, SIIIA, and GIIIA Mar Drugs. 2019 Mar 19;17(3):180. </a> <br><strong>Products Related to μ-Conotoxin SIIIA can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>