12-Oxo-leukotriene B4
12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions[1]. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC50 of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC50 of 170 nM[2].
Product Specifications
CAS Number
136696-10-1
Product Name Alternative
12-Oxo-LTB4
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12-oxo-leukotriene-b4.html
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\CC(/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O)=O
Molecular Formula
C20H30O4
Molecular Weight
334.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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