12-Oxo-leukotriene B4

12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions[1]. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC50 of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC50 of 170 nM[2].

Product Specifications

CAS Number

[136696-10-1]

Product Name Alternative

12-Oxo-LTB4

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/12-oxo-leukotriene-b4.html

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\CC(/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O)=O

Molecular Formula

C20H30O4

Molecular Weight

334.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Khanapure S P, et al., 12-Oxo-LTB4, a key pivotal intermediate in LTB4 metabolism[J]. The Journal of Organic Chemistry, 1995, 60 (6) : 1806-1813.|[2]Powell WS, et al., Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels. J Pharmacol Exp Ther. 1996 Feb;276 (2) :728-36.