(R) -Thalidomide

(R) -Thalidomide ((R) - (+) -Thalidomide) is the R-enantiomer of Thalidomide. (R) -Thalidomide has psychomotor stabilizing properties[1][2].

Product Specifications

CAS Number

[2614-06-4]

Product Name Alternative

(R) - (+) -Thalidomide

UNSPSC

12352005

Hazard Statement

H302, H360

Target

Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-thalidomide.html

Purity

99.80

Solubility

DMSO : 15 mg/mL (ultrasonic; warming)

Smiles

O=C1N([C@H](CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O

Molecular Formula

C13H10N2O4

Molecular Weight

258.23

Precautions

H302, H360

References & Citations

[1]Murphy S, et al. Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU. J Pharm Pharmacol. 2007 Jan;59 (1) :105-14.|[2]Eriksson T, et al. Intravenous formulations of the enantiomers of thalidomide: pharmacokinetic and initial pharmacodynamic characterization in man. J Pharm Pharmacol. 2000 Jul;52 (7) :807-17.