Cucurbitacin C
Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling[1].
Product Specifications
CAS Number
[5988-76-1]
UNSPSC
12352211
Target
Akt; Apoptosis
Type
Natural Products
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cucurbitacin-c.html
Solubility
10 mM in DMSO
Smiles
OC[C@]12[C@](CC=C3[C@@]2([H])CC[C@H](C3(C)C)O)([H])[C@]4([C@](CC1=O)([C@@]([C@@H](C4)O)([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)C)C
Molecular Formula
C32H48O8
Molecular Weight
560.72
References & Citations
[1]Wu D, et al. In Vitro and In Vivo Antitumor Activity of Cucurbitacin C, a Novel Natural Product From Cucumber. Front Pharmacol. 2019 Nov 8;10:1287.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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