Cucurbitacin C

Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling[1].

Product Specifications

CAS Number

[5988-76-1]

UNSPSC

12352211

Target

Akt; Apoptosis

Type

Natural Products

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cucurbitacin-c.html

Solubility

10 mM in DMSO

Smiles

OC[C@]12[C@](CC=C3[C@@]2([H])CC[C@H](C3(C)C)O)([H])[C@]4([C@](CC1=O)([C@@]([C@@H](C4)O)([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)C)C

Molecular Formula

C32H48O8

Molecular Weight

560.72

References & Citations

[1]Wu D, et al. In Vitro and In Vivo Antitumor Activity of Cucurbitacin C, a Novel Natural Product From Cucumber. Front Pharmacol. 2019 Nov 8;10:1287.