TUG-424

TUG-424 is a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 of 32 nM. TUG-424 significantly increases glucose-stimulated insulin secretion at 100 nM. TUG-424 may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity[1]. TUG-424 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1082058-99-8]

UNSPSC

12352005

Hazard Statement

H319, H410

Target

Free Fatty Acid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tug-424.html

Purity

99.68

Solubility

10 mM in DMSO|DMSO : ≥ 10mg/mL

Smiles

OC(CCC(C=C1)=CC=C1C#CC2=C(C)C=CC=C2)=O

Molecular Formula

C18H16O2

Molecular Weight

264.32

Precautions

H319, H410

References & Citations

[1]Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes J. Med. Chem., 2008, 51 (22), pp 7061-7064|[2]Christiansen E, et al. Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA (1) /GPR40), a potential target for the treatment of type II diabetes. J Med Chem. 2008 Nov 27;51 (22) :7061-4.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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