N-Butanoyl-L-homoserine lactone

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].

Product Specifications

CAS Number

[67605-85-0]

Product Name Alternative

C4-HSL; N-Butyryl-L-homoserine lactone

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; Bacterial

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-butanoyl-l-homoserine-lactone.html

Purity

98.77

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCC(N[C@H]1CCOC1=O)=O

Molecular Formula

C8H13NO3

Molecular Weight

171.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1|[2]Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14 (2) :e0212041.|[3]Feng Sun, et al. Advance of the diversity of bacterial quorum sensing and quorum quenching. National Natural Science Foundation of China. Published online 9 October 2018.