Lariciresinol

Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC50 of 6.97 μM; Ki of 0.046 μM) . Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[27003-73-2]

UNSPSC

12352005

Hazard Statement

H400

Target

Apoptosis; Bcl-2 Family; Fungal; Glycosidase; NF-κB; TGF-β Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB; TGF-beta/Smad

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lariciresinol.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic) |Methanol : 25 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@](C(C=C2)=CC(OC)=C2O)([H])OC[C@@H]1CC(C=C3)=CC(OC)=C3O

Molecular Formula

C20H24O6

Molecular Weight

360.40

Precautions

H400

References & Citations

[1]Nakatsubo T, et al. Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis. J Biol Chem. 2008;283 (23) :15550-15557.|[2]Ma ZJ, et al. Lariciresinol induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway. Eur J Pharmacol. 2018 Feb 15;821:1-10.|[3]Soltani M, et al. Investigating the cytotoxic effect of pinoresinol and lariciresinol on breast cancer cell line SKBr3. Modares Journal of Biotechnology, 2020, 11 (1) : 13-20.|[4]Sun Y, et al. Lariciresinol Induces Apoptosis and Inhibits Migration-Invasion of Patient-Derived Hypertrophic Scar Fibroblasts via Preventing Accumulation of Collagen. Revista Brasileira de Farmacognosia, 2024, 34 (5) : 1024-1031.|[5]Hwang B, et al. Antifungal activity of lariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans. Biochem Biophys Res Commun. 2011 Jul 8;410 (3) :489-93.|[6]Alam MB, et al. Lariciresinol Displays Anti-Diabetic Activity through Inhibition of α-Glucosidase and Activation and Enhancement of Insulin Signaling. Mol Nutr Food Res. 2022 Jul;66 (13) :e2100751.|[7]Zhao X, et al. Lariciresinol protects rats from complete Freund's adjuvant induced arthritis in rats via modulation of transforming growth factor-β and nuclear factor kappa B pathway: An in vivo and in silico study. Chem Biol Drug Des. 2023 Jul;102 (1) :168-176.|[8]Saarinen NM, et al. Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. Int J Cancer. 2008 Sep 1;123 (5) :1196-204.