Bmi-1 Rabbit pAb (F270)
BMI1 proto-oncogene, polycomb ring finger (BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],
Product Specifications
Background
UniProt
P35226
Swiss Prot
P35226
Reactivity
Human
Immunogen
Recombinant Protein derived from human Bmi-1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Molecular Weight
37-43kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
37-43kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm .
Other Product Names
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene ID (Human)
100532731
Available Sizes
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