2-Amino-2- (p-tolyl) acetic acid

2-Amino-2- (p-tolyl) acetic acid is used for optimizing azide skeleton, and is the intermediate in the synthesis of 1,3, 4-thiadiazole compounds. 1,3,4-thiadiazole compounds exhibit potential anti-cancer activity, and inhibit glutaminase (GLSI) [1][2].

Product Specifications

CAS Number

[13227-01-5]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Glutaminase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-amino-2-p-tolyl-acetic-acid.html

Purity

97.0

Solubility

DMSO : 50 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=C(O)C(N)C1=CC=C(C)C=C1

Molecular Formula

C9H11NO2

Molecular Weight

165.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Kalie A M, et al. Cytosolic Delivery of Proteins by Bioreversible Esterification. JAmChem. 2017. 139 (41) :14396–14398.|[2]Finlay MRV, et al. Preparation of 1,3,4-thiadiazole compounds and their use in treating cancer: World Intellectual Property Organization, WO2017093301[P]. 2017-06-08.