CYN 154806
CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2].
Product Specifications
CAS Number
183658-72-2
UNSPSC
12352209
Target
Somatostatin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/cyn-154806.html
Purity
99.97
Solubility
H2O : 12.5 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC([C@@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@@H](C(N)=O)CC2=CC=C(C=C2)O)=O)NC([C@@H](NC(C)=O)CC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)CC4=CC=C(C=C4)O)N[C@@H]1CC5=CNC6=CC=CC=C56
Molecular Formula
C56H68N12O14S2
Molecular Weight
1197.34
References & Citations
[1]Bass RT, et al. Identification and characterization of novel somatostatin antagonists. Mol Pharmacol. 1996 Oct;50 (4) :709-15.|[2]Feniuk W, et al. Selective somatostatin sst (2) receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology. 2000 Jun 8;39 (8) :1443-50.|[3]Takeuchi K, et al. Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Cholinergic Stimulation of Gastric Acid Secretion: Relation to D Cell/Somatostatin. Front Pharmacol. 2016 Aug 30;7:278.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
SSTR2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Cytokeratin 10 Recombinant Rabbit Monoclonal Antibody [ST05-43]](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea81306/imageurl/et1609-75.webp)
ET1609-75 100 µL
Cytokeratin 10 Recombinant Rabbit Monoclonal Antibody [ST05-43]
Sign In for Pricing
View Details ![Nucleobindin 1 (NUCB1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1G3]](https://cdn.genprice.uk/products/937/68dd1b6d061270361ea16ea4/imageurl/ta504035bm.webp)
TA504035BM 100 µL
Nucleobindin 1 (NUCB1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1G3]
Sign In for Pricing
View Details 
