HPO-DAEE
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE) . HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways[1].
Product Specifications
CAS Number
1895934-61-8
Product Name Alternative
4-Hydroperoxy-2-decenoic acid ethyl ester
UNSPSC
12352211
Target
HDAC; Reactive Oxygen Species (ROS) ; SOD
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hpo-daee.html
Solubility
10 mM in DMSO
Smiles
CCCCCCC(OO)/C=C/C(OCC)=O
Molecular Formula
C12H22O4
Molecular Weight
230.30
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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