Anti-TNF-R1 Antibody

Rabbit Polyclonal Antibody specific to TNF-R1 Antibody

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Tumor necrosis factor receptor 1 (TNF-R1), Tumor necrosis factor receptor type I (TNF-RI; TNFR-I), p55, p60

UniProt

P19438

Host

Rabbit

Reactivity

Human, Mouse, Rat, Rabbit, Hamster, Sheep, Monkey, Bovine, Canine, Porcine, Drosophila, Xenopus, Yeast

Immunogen

A synthetic peptide corresponding to a portion of mouse TNF-R1. This sequence is completely conserved in rat and human. Accession no. P25118.

Target

TNF-R1

Clonality

Polyclonal

Type

Antibody

Applications

WB, IHC

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by peptide affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Additionnal Information

Western Blot: 1ug/ml Immunohistochemistry(paraffin): 1-10ug/ml Immunoprecipitation: 12.5ug/ml These are recommended concentrations. End user should determine optimal concentrations for their applications.

Storage Conditions

Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot and store at -20°C.

Specificity

TNF-R1 Antibody

Formulation

PBS containing 50% glycerol and 0.09% sodium azide.

Target Background

Tumor necrosis factor alpha (TNF-alpha), also known as cachetin, is a memberof the TNF superfamily of cytokines that is a potent lymphoid factor with effecs on a wide range of target cells. TNF exerts proinflamatory signals va binding and inducing trimerization of TNF-receptor 1 (TNF-R1) expressed on most normal and transformed cells. TNF signaling regulates hematopoiesis, differentiation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune surveillance. Dysregulation of TNF or its receptors is implicated in numerous diseases including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.