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BI-6015

BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes[1].

Product Specifications

CAS Number

[93987-29-2]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Orphan Nuclear Receptor; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bi-6015.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(N1C2=CC=CC=C2N=C1C)(C3=CC([N+]([O-])=O)=CC=C3C)=O

Molecular Formula

C15H13N3O4S

Molecular Weight

331.35

Precautions

H315, H319

References & Citations

[1]Kiselyuk A, et, al. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19 (7) :806-18.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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