DOTA-JR11
DOTA-JR11 is a somatostatin receptor 2 (SSTR2) antagonist. DOTA-JR11 can be labeled by 68Ga, used for paired imaging in neuroendocrine tumors (NETs) research[1]. DOTA-JR11 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
Product Specifications
CAS Number
1039726-31-2
Product Name Alternative
Satoreotide tetraxetan
UNSPSC
12352209
Target
Radionuclide-Drug Conjugates (RDCs) ; Somatostatin Receptor
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dota-jr11.html
Purity
99.14
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C(N[C@H](C(N[C@@](C(N[C@@H](CSSC[C@H](C(N1)=O)NC([C@@H](NC(CN2CCN(CCN(CCN(CC2)CC(O)=O)CC(O)=O)CC(O)=O)=O)CC3=CC=C(C=C3)Cl)=O)C(N[C@@H](C(N)=O)CC4=CC=C(C=C4)O)=O)=O)([H])[C@H](O)C)=O)CCCCN)=O)CC5=CC=C(C=C5)NC(N)=O)[C@@H]1CC6=CC=C(C=C6)NC([C@@H]7CC(NC(N7)=O)=O)=O
Molecular Formula
C74H98ClN19O21S2
Molecular Weight
1689.27
References & Citations
[1]Krebs S, et al. Comparison of 68Ga-DOTA-JR11 PET/CT with dosimetric 177Lu-satoreotide tetraxetan (177Lu-DOTA-JR11) SPECT/CT in patients with metastatic neuroendocrine tumors undergoing peptide receptor radionuclide therapy. Eur J Nucl Med Mol Imaging. 2020 Dec;47 (13) :3047-3057.|[2]Xie Q, et al. Synthesis, preclinical evaluation, and a pilot clinical imaging study of [18F]AlF-NOTA-JR11 for neuroendocrine neoplasms compared with [68Ga]Ga-DOTA-TATE. Eur J Nucl Med Mol Imaging. 2021 Sep;48 (10) :3129-3140.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
RDC Peptide
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![VILIP1 (VSNL1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2D8]](https://cdn.genprice.uk/products/937/6868c3a0994c49e6dc3fb740/imageurl/ta802260bm.webp)
TA802260BM 100 µL
VILIP1 (VSNL1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2D8]
Sign In for Pricing
View Details ![GNPAT Mouse Monoclonal Antibody [Clone ID: OTI1H1]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908a5f/imageurl/cf811140.webp)
TRC-A633333-10MG 10 mg
2-(2-Aminothiazol-4-yl)acetic acid hydrochloride
Sign In for Pricing
View Details 
#30104-T 1 Kit
MemBrite® Fix-ST 755/777 Cell Surface Staining Kit, 100 Reactions
Sign In for Pricing
View Details