Trifluoromethyl-tubercidin

Trifluoromethyl-tubercidin (TFMT) is an inhibitor of 2'-O-ribose methyltransferase 1 (MTr1) . Trifluoromethyl-tubercidin can inhibit the replication of influenza A and B viruses by interfering with the cap-snatching process of the influenza virus. Trifluoromethyl-tubercidin has antiviral activity and low toxicity[1].

Product Specifications

CAS Number

[1854086-05-7]

Product Name Alternative

TFMT

UNSPSC

12352005

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/trifluoromethyl-tubercidin.html

Purity

99.12

Solubility

DMSO : 3.34 mg/mL (ultrasonic; warming)

Smiles

O[C@H]1[C@@H](O[C@@H]([C@H]1O)CO)N2C3=NC=NC(N)=C3C(C(F)(F)F)=C2

Molecular Formula

C12H13F3N4O4

Molecular Weight

334.25

References & Citations

[1]Yuta Tsukamoto, et al. Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science. 2023 Feb 10;379 (6632) :586-591.