σ1 Receptor antagonist 4
σ1 Receptor antagonist 4 (compound TC1) is a selective sigma1 (σ1) receptor antagonist with a Ki of 10 nM. σ1 Receptor antagonist 4 is weakly active at σ2 receptor (Ki of 370 nM) and has no activity at dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters[1].
Product Specifications
CAS Number
362512-81-0
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/σ1-receptor-antagonist-4.html
Smiles
OC12[C@H]3[C@@H]4C(C5C2C6[C@@H]3[C@H]4C5C6)N1CCC7=CC(F)=CC=C7
Molecular Formula
C19H20FNO
Molecular Weight
297.37
References & Citations
[1]Xiang Liu, et al. Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. Eur J Pharmacol. 2007 Jan 19;555 (1) :37-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor; Sigma 2 Receptor
Frequently Asked Questions
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