JNJ-26990990
JNJ-26990990 is a broad-spectrum antiepileptic agent with oral activity. JNJ-26990990 can inhibit voltage-gated Na+ channels and N-type Ca2+ channels, but has a very weak inhibitory effect on human carbonic anhydrase-II (IC50 = 110 μM) [1].
Product Specifications
CAS Number
877316-38-6
UNSPSC
12352005
Target
Calcium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-26990990.html
Solubility
10 mM in DMSO
Smiles
O=S(N)(NCC1=CSC2=CC=CC=C21)=O
Molecular Formula
C9H10N2O2S2
Molecular Weight
242.32
References & Citations
[1]Parker MH, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N- ((benzo[b]thien-3-yl) methyl) sulfamide (JNJ-26990990) into human clinical studies. J Med Chem. 2009;52 (23) :7528-7536.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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