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4',5'-Didehydro-5'-deoxyuridine

4',5'-Didehydro-5'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Product Specifications

CAS Number

14365-63-0

Product Name Alternative

1- (5-Deoxy-beta-D-erythro-pent-4-enofuranosyl) uracil

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-5-didehydro-5-deoxyuridine.html

Purity

99.25

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=C1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O1

Molecular Formula

C9H10N2O5

Molecular Weight

226.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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