4',5'-Didehydro-5'-deoxyuridine
4',5'-Didehydro-5'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[14365-63-0]
Product Name Alternative
1- (5-Deoxy-beta-D-erythro-pent-4-enofuranosyl) uracil
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-5-didehydro-5-deoxyuridine.html
Purity
99.25
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=C1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O1
Molecular Formula
C9H10N2O5
Molecular Weight
226.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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