NVP-SAA164

NVP-SAA164 is an orally active nonpeptide kinin B1 receptor antagonist. NVP-SAA164 reverses CFA (Complete Freund's adjuvant) (HY-153808) -induced mechanical hyperalgesia and desArg10KD-induced hyperalgesia in hB1-KI mice, and is inactive in a model of inflammatory pain in wild-type mice[1].

Product Specifications

CAS Number

[312722-60-4]

UNSPSC

12352005

Target

Bradykinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nvp-saa164.html

Smiles

O=C(N1CCOCC1)C2=CC(S(=O)(N3CCC(CC3)C(N4CCN(CC4)C)=O)=O)=CC=C2NCC(C5=CC=CC=C5)C6=CC=CC=C6

Molecular Formula

C36H45N5O5S

Molecular Weight

659.84

References & Citations

[1]Fox A, et al. Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor. Br J Pharmacol. 2005 Apr;144 (7) :889-99.