NA-Ir
Product Specifications
UNSPSC Description
NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H2S levels[1].
Target Antigen
Autophagy; Ferroptosis; Mitochondrial Metabolism; STING
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Immunology/Inflammation;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/na-ir.html
Smiles
CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=CC=CC=[N]63)([C-]7=CC=CC=C7C8=[N]4C=CC=C8)[N]9=CC=C(COC(CCN%10C(C%11=C%12C(C%10=O)=CC=C(C%12=CC=C%11)N=[N+]=[N-])=O)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Molecular Weight
1138.04
References & Citations
[1]Li Y, et al. Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy. J Med Chem. 2024 Sep 26;67(18):16235-16247.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162944/NA-Ir-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162944/
Clinical Information
No Development Reported
CAS Number
3031762-97-4
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