NA-Ir

NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H2S levels[1].

Product Specifications

CAS Number

[3031762-97-4]

UNSPSC

12352005

Target

Autophagy; Ferroptosis; Mitochondrial Metabolism; STING

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/na-ir.html

Smiles

CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=CC=CC=[N]63)([C-]7=CC=CC=C7C8=[N]4C=CC=C8)[N]9=CC=C(COC(CCN%10C(C%11=C%12C(C%10=O)=CC=C(C%12=CC=C%11)N=[N+]=[N-])=O)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

Molecular Formula

C49H36F6IrN8O4P

Molecular Weight

1138.04

References & Citations

[1]Li Y, et al. Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium (III) Complex for Cancer-Specific Therapy. J Med Chem. 2024 Sep 26;67 (18) :16235-16247.