GAK inhibitor 49 (hydrochloride)
GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2[1].
Product Specifications
CAS Number
[2930378-91-7]
UNSPSC
12352005
Target
Cyclin G-associated Kinase (GAK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gak-inhibitor-49-hydrochloride.html
Purity
99.52
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C(OC)=CC(NC2=CC=NC3=CC(OC)=C(OC)C=C23)=C1.[H]Cl
Molecular Formula
C20H23ClN2O5
Molecular Weight
406.86
References & Citations
[1]Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13 (1) :48-66.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
008864 2.5 mg
4’,5-Di-O-acetyl Genistein 7- (Tri-O-acetyl-β-D-glucuronic Acid Methyl Ester)
Sign In for Pricing
View Details ![Anti-Mycobacterium Avium [Clone JD11-366.1] - 1.0 mg](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
18103-1.0mg 1 mg
Anti-Mycobacterium Avium [Clone JD11-366.1] - 1.0 mg
Sign In for Pricing
View Details MBS1208420-01 0.02 mg (E-Coli)
Recombinant Arabidopsis thaliana Agamous-like MADS-box protein AGL5 (AGL5)
Sign In for Pricing
View Details MBS1208420-02 0.1 mg (E-Coli)
Recombinant Arabidopsis thaliana Agamous-like MADS-box protein AGL5 (AGL5)
Sign In for Pricing
View Details MBS1208420-03 0.02 mg (Yeast)
Recombinant Arabidopsis thaliana Agamous-like MADS-box protein AGL5 (AGL5)
Sign In for Pricing
View Details