ROCK-IN-5

ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK, ERK, GSK, and AGC protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research[1].

Product Specifications

CAS Number

[692870-25-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

ERK; GSK-3; ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rock-in-5.html

Purity

98.0

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC(C2=CC=NC=C2)=CS1)CC3=C(F)C=CC=C3Cl

Molecular Formula

C16H11ClFN3OS

Molecular Weight

347.79

Precautions

H302, H315, H319

References & Citations

[1]Jingrong Cao, et al. Compositions useful as inhibitors of rock and other protein kinases. WO2004041813A1.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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