ROCK-IN-5
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK, ERK, GSK, and AGC protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research[1].
Product Specifications
CAS Number
[692870-25-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
ERK; GSK-3; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rock-in-5.html
Purity
98.0
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(C2=CC=NC=C2)=CS1)CC3=C(F)C=CC=C3Cl
Molecular Formula
C16H11ClFN3OS
Molecular Weight
347.79
Precautions
H302, H315, H319
References & Citations
[1]Jingrong Cao, et al. Compositions useful as inhibitors of rock and other protein kinases. WO2004041813A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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