Antitumor agent-165
Antitumor agent-165 (Compound 10l) is a potent focal adhesion kinase (FAK) inhibitor. Antitumor agent-165 exhibits effective antiproliferative activity against CAPAN-1, PANC-1, PATU-T, SUIT-2, BxPC-3, PDAC-3 and PANC-1 GR with IC50s in the range of 1.04-3.44 μM[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-165.html
Smiles
CN1C=C(C2=NN3C(S2)=NC(C4=CC=CO4)=C3)C5=C1C=CC=C5
Molecular Formula
C17H12N4OS
Molecular Weight
320.37
References & Citations
[1]Carbone D, et al. Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: Synthesis, mechanistic Insights and promising antitumor and safety profile[J]. bioRxiv, 2024: 2024.05. 27.596063.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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