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Antitumor agent-165

Antitumor agent-165 (Compound 10l) is a potent focal adhesion kinase (FAK) inhibitor. Antitumor agent-165 exhibits effective antiproliferative activity against CAPAN-1, PANC-1, PATU-T, SUIT-2, BxPC-3, PDAC-3 and PANC-1 GR with IC50s in the range of 1.04-3.44 μM[1].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352005

Target

FAK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-165.html

Smiles

CN1C=C(C2=NN3C(S2)=NC(C4=CC=CO4)=C3)C5=C1C=CC=C5

Molecular Formula

C17H12N4OS

Molecular Weight

320.37

References & Citations

[1]Carbone D, et al. Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: Synthesis, mechanistic Insights and promising antitumor and safety profile[J]. bioRxiv, 2024: 2024.05. 27.596063.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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