L-685,458

<strong>L-685,458</strong> <strong>Catalog number:</strong> MDP0761 <strong>CAS Number: </strong>N/A <strong>Sequence: </strong>[(2R,4R,5S)-2-Benzyl-5-(t-butyloxycarbonylamino)-4-hydroxy-6-phenylhexanoyl]-L-leucyl-L-phenylalanine amide <strong>Amount:</strong> 1 mg <strong>Molecular Weight:</strong> 672.8 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Xiong K, Clough RW, Luo XG, Struble RG, Li YM, Yan XX. [3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: relevance to Abeta genesis and presence of active presenilin-1 components Brain Res. 2007 Jul 9;1157:81-91. 2: Shearman MS, Beher D, Clarke EE, Lewis HD, Harrison T, Hunt P, Nadin A, Smith AL, Stevenson G, Castro JL. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity Biochemistry. 2000 Aug 1;39(30):8698-704. 3: Zhang X, Sui S, Wang L, Li H, Zhang L, Xu S, Zheng X. Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin J Cell Physiol. 2020 Apr;235(4):3425-3437. 4: Hitzenberger M, Zacharias M. Uncovering the Binding Mode of γ -Secretase Inhibitors ACS Chem Neurosci. 2019 Aug 21;10(8):3398-3403. 5: Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M. Semagacestat Is a Pseudo-Inhibitor of γ-Secretase Cell Rep. 2017 Oct 3;21(1):259-273. 6: Yao J, Duan L, Fan M, Wu X. Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells Oral Dis. 2007 Nov;13(6):555-63. 7: Stanga S, Vrancx C, Tasiaux B, Marinangeli C, Karlström H, Kienlen-Campard P. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing J Cell Mol Med. 2018 Feb;22(2):823-833. 8: Mamaeva OA, Kim J, Feng G, McDonald JM. Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells J Cell Biochem. 2009 Jan 1;106(1):25-32. 9: Choi YH, Gwon AR, Jeong HY, Park JS, Baik SH, Arumugam TV, Jo DG. Contribution of gamma-secretase to calcium-mediated cell death Neurosci Lett. 2010 Jan 29;469(3):425-8. <a href="https://pubmed.ncbi.nlm.nih.gov/21622856">10: Kang JH, Lee EH, Park SW, Chung IY. MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways J Immunol. 2011 Jul 1;187(1):222-9. </a> <br><strong>Products Related to L-685,458 can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>