Octyl-α-ketoglutarate

Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD[1].

Product Specifications

CAS Number

[876150-14-0]

Product Name Alternative

1-Octyl 2-oxopentanedioate

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/octyl-α-ketoglutarate.html

Concentration

38.71 mM * 100 μL in Methyl acetate

Purity

99.9

Smiles

O=C(OCCCCCCCC)C(CCC(O)=O)=O

Molecular Formula

C13H22O5

Molecular Weight

258.31

Precautions

H225, H319, H336

References & Citations

[1]MacKenzie ED, et al. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol. 2007 May;27 (9) :3282-9.