DMPO

DMPO is a cell permeable hydrophillic spin trap agent for superoxide detection[1].

Product Specifications

CAS Number

[3317-61-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NO Synthase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dmpo.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 175 mg/mL (ultrasonic)

Smiles

CC1(C)[N+]([O-])=CCC1

Molecular Formula

C6H11NO

Molecular Weight

113.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Ranguelova K, Mason RP. The fidelity of spin trapping with DMPO in biological systems. Magn Reson Chem. 2011;49 (4) :152-158. |[2]Konaka R, Kawai M, Noda H, Kohno M, Niwa R. Synthesis and evaluation of DMPO-type spin traps. Free Radic Res. 1995;23 (1) :15-25. |[3]Das A, et al. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation. Br J Pharmacol. 2014 May;171 (9) :2321-34.|[4]Britigan BE, Hamill DR. Effect of the spin trap 5,5 dimethyl-1-pyrroline-N-oxide (DMPO) on human neutrophil function: novel inhibition of neutrophil stimulus-response coupling? Free Radic Biol Med. 1990;8 (5) :459-70. |[5]Zhai Z, et al. The spin trap 5,5-dimethyl-1-pyrroline N-oxide inhibits lipopolysaccharide-induced inflammatory response in RAW 264.7 cells. Life Sci. 2012 Mar 10;90 (11-12) :432-9.|[6]Woo suk Chung, et al. Antinociceptive Effect of Intraperitoneally Administered 5,5-dimethyl-1-pyrroline N-oxide on Formalin Induced Nociception in Rats. Korean Journal of Anesthesiology 2008;54 (3) :S35-S39.