Timosaponin AIII
Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM.
Product Specifications
CAS Number
41059-79-4
UNSPSC
12352005
Hazard Statement
H302
Target
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Timosaponin_AIII.html
Purity
99.73
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@H](C)CO4)([H])C[C@@]1([H])[C@@](CC[C@@]5([H])[C@@]6(CC[C@H](O[C@@](O[C@H](CO)[C@H](O)[C@@H]7O)([H])[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@H]8CO)C5)C)([H])[C@]6([H])CC2
Molecular Formula
C39H64O13
Molecular Weight
740.92
Precautions
H302
References & Citations
[1]Lee B, et al. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacol Biochem Behav. 2009 Aug;93 (2) :121-7.|[2]King FW, et al. Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One. 2009 Sep 30;4 (9) :e7283.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
Frequently Asked Questions
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