Uridine triacetate

Uridine triacetate (Tri-O-acetyl uridine) is an orally active proagent of Uridine (HY-B1449) . Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate is used for the research of 5-fluorouracil (5-FU) and capecitabine toxicity, or early-onset cardiac or central nervous system (CNS) [1][2].

Product Specifications

CAS Number

[4105-38-8]

Product Name Alternative

Tri-O-acetyl uridine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/uridine-triacetate.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL|H2O : 10 mg/mL (ultrasonic)

Smiles

O=C1NC(C=CN1[C@H]2[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2)=O

Molecular Formula

C15H18N2O9

Molecular Weight

370.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123 (2) :345-356.|[2]Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51 (6) :484-8.|[3]Rolando A G Garcia, et al. Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency. Toxicol Appl Pharmacol. 2018 Aug 15;353:67-73. |[4]Siennah R Miller, et al. Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling. Mol Pharmacol. 2021 Feb;99 (2) :147-162.