LSN3353871
LSN3353871 is a potent inhibitor of lipoprotein (a) (Lp (a) ) that can binds to Kringle IV (KIV) 8, KIV7-8 and KIV5-8, with Kd of 756 nM, 605 nM and 423 nM, respectively. LSN3353871 disrupts the formation of Lp (a) with the IC50 of 1.69 μM. LSN3353871 has oral bioactivity[1].
Product Specifications
CAS Number
[2565657-20-5]
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/lsn3353871.html
Purity
99.62
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC([C@@H](CC1=CC=CC=C1)[C@@H]2CNCC2)=O.Cl
Molecular Formula
C13H18ClNO2
Molecular Weight
255.74
References & Citations
[1]Nuria Diaz, et al. Discovery of potent small-molecule inhibitors of lipoprotein (a) formation. Nature. 2024 May;629 (8013) :945-950.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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